Efficacy, biocompatibility and degradability of carbon nanoparticles for photothermal therapy of lung cancer
نویسندگان
چکیده
Aim: To investigate near infrared-induced phototoxicity toward lung cancer cells, and the biodegradability effect on immune cells of glucose-derived carbon nanoparticles (CNPs). Methods: The human A549 adenocarcinoma cell line was used as a model to study CNPs. demonstrated in primary neutrophils macrophages. Results: Near infrared-activated CNPs elicited rapid death, characterized by elevation heat shock proteins induction DNA damage. were found be noncytotoxic macrophages susceptible biodegradation when cocultured with neutrophils. Conclusions: Our results identify promising platforms for photothermal therapy cancer.
منابع مشابه
development of different optical methods for determination of glucose using cadmium telluride quantum dots and silver nanoparticles
a simple, rapid and low-cost scanner spectroscopy method for the glucose determination by utilizing glucose oxidase and cdte/tga quantum dots as chromoionophore has been described. the detection was based on the combination of the glucose enzymatic reaction and the quenching effect of h2o2 on the cdte quantum dots (qds) photoluminescence.in this study glucose was determined by utilizing glucose...
application and construction of carbon paste modified electrodes developed for determination of metal ions in some real samples
ساخت الکترودهاِی اصلاح شده ِیکِی از چالشهاِی همِیشگِی در دانش شیمِی بوِیژه شیمِی تجزیه مِی باشد ،که با در نظر گرفتن سادگِی ساخت، کاربردی بودن و ارزان بودن روش مِی توان به باارزش بودن چنِین سنسورهاِی پِی برد.آنچه که در ادامه آورده شده به ساخت و کاربرد الکترودهاِی اصلاح شده با استفاده از نانو ذرات در اندازه گِیرِی ولتامترِی آهن وکادمِیم اشاره دارد. کار اول اختصاص دارد به ساخت الکترود خمِیر کربن اصلاح شده با لِیگاند داِ...
15 صفحه اولPolydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy
Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver ...
متن کاملPhotothermal therapy of cancer cells mediated by blue hydrogel nanoparticles.
AIM The aim of this study was to investigate in vitro the utility of biologically compatible, nontoxic and cell-specific targetable hydrogel nanoparticles (NPs), which have Coomassie® Brilliant Blue G dye (Sigma-Aldrich, MO, USA) covalently linked into their polyacrylamide matrix, as candidates for photothermal therapy (PTT) of cancer cells. MATERIALS & METHODS Hydrogel NPs with Coomassie Bri...
متن کاملPolyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy
In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs). The UCNP induces upconversion luminescence for imaging and photothermal conversion properties are due to PANPs. In vitro experiments showed that the UCNPs-PANPs were nontoxic to cells even at a high concentration (800 µg mL(-1)). Blood analysis and histo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanomedicine
سال: 2021
ISSN: ['1743-5889', '1748-6963']
DOI: https://doi.org/10.2217/nnm-2021-0009